The mod also drives menus and lobbies: profile switching, character select with an optional seed, and hosting or joining co-op games. The README flags multiplayer support as beta. It is the most-starred STS2 bridge, and several bots in this index build on it or on forks of it.
Projects / Game interface
STS2MCP
Slay the Spire 2 mod that exposes game state and actions over a localhost REST API, with an optional MCP server so language-model agents can play. Covers single player and co-op (beta).